general
- Generic Name : Zoledronic Acid
- Pronunciation : ZOE-le-DRON-ik AS-id
- ICD Code : Y57.9
- Therapeutic Classification : Bone Enhancers
- Trade Names/Brand Names of Zoledronic Acid(India) :
Cytozol, Blaztere Inj (4mg), Zoldria, Rokfos (5mg), Blaztere, Zoleget, Zifonate - International: Reclast, Zometa, Aclasta
prescription
This bisphosphonate is primarily for osteoporosis prevention/treatment in men and postmenopausal women. Also for Paget’s disease and steroid-induced osteoporosis. It lowers calcium release from bones.
risk factors
- Avoid in those allergic, with paralysis, or during pregnancy/lactation
- Ensure adequate levels of calcium and Vitamin D. Patients may experience kidney impairment
side effects
- Common: Fever, muscle pain, headache, joint pain, extremity pain.
- Blood: Anemia.
- Metabolic: Dehydration, appetite loss.
- CNS: Dizziness.
- Heart: Atrial fibrillation, vascular disorders, hypertension.
- GI: Nausea, diarrhea, vomiting, abdominal pain.
- Musculoskeletal: Shoulder pain, neck pain, fractures, muscle spasms.
- General: Fever, flu-like symptoms, fatigue, chills, weakness, peripheral edema, uneasiness, chest pain.
dosage
The recommended intravenous dose is 4mg/100mL administered over 15 minutes; it may be repeated after one week.
how to take
It is provided as a solution for injection and should be administered by a healthcare provider.
warning
- Use with caution in patients with a history of kidney disease, dehydration, asthma, during pregnancy, and breastfeeding
- Stay hydrated; ensure adequate fluid intake
- Conduct regular oral examinations in those at risk of osteonecrosis of the jaws
- Monitor serum electrolytes, calcium, phosphate, and magnesium levels
- Suspend treatment if kidney function worsens
- May cause dizziness; avoid driving or operating machinery while using this medication
storage
Store between 15-30°C