general
- Generic Name : Urokinase
- Pronunciation : ure-oh-KYE-nase
- ICD Code : Y43.6
- Therapeutic Classification : Enzymes
- Trade Names/Brand Names of Urokinase(India):
Uroken,Uni -Kinase (7.5 Lacs iu),Urokinase (5 Lacs iu),Urokinase (7.5 Lacs iu),Urokinase (0.2 lacs iu),Dukinase (100000iu),Medinase,Dukinase (25000iu),Uropase (7.5 Lacs iu),Dabunase,Kd -Unase,Urokinase 250000IU Injection,Dukinase (50000iu),Urokinase (10 Lacs iu),Dukinase (75000iu),Uni -Kinase (5 Lacs iu),Uni -Kinase (10 Lacs iu),Dukinase,Dabunase (5 Lac iu),Uni -Kinase (2.5 lacs iu),Medinase (5 Lacs iu),Urolyte,Kd -Unase (7.5 Lacs iu),Uropase (5 Lacs iu),Uropase,Kd -Unase (5 Lacs iu),Uroken (10 Lacs iu),Urokinase (0.5 lacs iu),Uropase (10 Lacs iu),Uroken (7.5 Lacs iu) - International :Kinlytic
prescription
Urokinase, a thrombolytic enzyme, is prescribed for deep vein thrombosis, heart attack, pulmonary embolism, and peripheral vascular occlusion, dissolving blood clots.
risk factors
Not recommended for patients with:
- Active internal bleeding
- History of stroke
- Recent (within 2 months) trauma, including brain and spinal cord surgery
- Brain aneurysm or tumor
- Known bleeding disorder
- Severe uncontrolled hypertension
- Allergy to the drug
side effects
- Most common: Severe bleeding.
- Heart: Heart attack, recurrent blood clots in the lungs, stroke.
- Blood: Decreased red blood cells and platelets.
- Miscellaneous: Excessive sweating.
- Potentially Fatal: Severe bleeding, severe allergic reactions, cholesterol embolization. Other side effects, including cardiac arrest and irregular heart rate, have also been observed in patients using urokinase.
dosage
For adults:
- Deep vein thrombosis; Pulmonary embolism: Initial dose of 4,400 units/kg over 10 minutes, then 4,400 units/kg/hr for 12-24 hours (deep vein thrombosis) or 12 hours (pulmonary embolism).
- Peripheral arterial thromboembolism (using a 2,000 units/ml solution): Administer via catheter directly into the clot at a rate of 4,000 units/minute for 2 hours.
- Heart Attack: Administer 250,000 IU over 10 minutes followed by 500,000 IU over the next hour.
how to take
It is available as a solution for injection, administered by a healthcare provider into the vein.
warning
- Avoid vascular punctures or invasive procedures.
- Exercise caution in patients with peptic ulcer disease, bleeding disorders, high blood pressure, heart infection, recent biopsy or surgery, recent injury, or allergies.
- Use with care to prevent injury, especially in patients with liver or kidney disease, coagulation defects, brain disease, diabetic retinal damage, pregnancy, recent surgery, childbirth, or trauma.
- Monitor for reperfusion heart rate during heart attack treatment.
- Increased risk of cerebral bleeding may occur.
storage
Injection: Store below 25°C in airtight containers at room temperature.