general
- Generic Name : Macimorelin
- Pronunciation : ma-si-moe-REL-in
- Therapeutic Classification : Diagnostic Agents
- Trade Names/Brand Name : Macrilen
prescription
- Macimorelin acetate is a growth hormone (GH) secretagogue receptor agonist which is prescribed to diagnose adult growth hormone deficiency (AGHD)
risk factors
Macimorelin allergy may occur in the following conditions:
- Children
- Body mass index (BMI) exceeding 40 kg/m2
- Deficiencies in sex hormones, thyroid hormones, and/or glucocorticoids
- Patients using medications that can impact pituitary GH secretion
side effects
- Gastrointestinal effects may include heightened appetite, nausea, diarrhea, increased hunger, and alterations in taste.
- Cardiovascular impacts could involve abnormal heart rhythm or an extended QT interval on an electrocardiogram (ECG).
- Nervous system-related side effects may manifest as headaches, dizziness, and fatigue.
- Respiratory issues may include infections of the respiratory tract.
- Skin-related symptoms might encompass excessive sweating and a sensation of feeling hot.
dosage
- The prescribed dosage is determined according to the patient’s specific body weight.
- It is administered as a sole dose of 0.5mg/kg body weight following an 8-hour fasting period.
how to take
- Patients with a weight < 120 kg should utilize one sachet
- While those with a weight > 120 kg should employ two sachets.
warning
- A patient must observe an 8-hour fasting period before consuming the macimorelin oral solution.
- Close monitoring is essential for patients with cardiac conditions to mitigate the potential risk of abnormal heart rhythm, which could result in sudden cardiac death.
- Individuals with lesions in the hypothalamus may require repeat testing, as there is a possibility of obtaining a false negative test result.
- Reconstitution of the solution should only be performed by a trained healthcare professional and administration should be conducted under medical supervision.
- The safety of using macimorelin during pregnancy and breastfeeding has not been established.
storage
A temperature range of 2°C to 8°C.