general
- Generic Name : Uridine triacetate
- Pronunciation : ure-i-deen-trye-as-e-tate
- Trade Names/Brand Names of Uridine triacetate: Vistogard, Xuriden
prescription
Uridine triacetate serves as a chemoprotectant, safeguarding against chemotherapy’s adverse effects. It’s also effective for treating hereditary orotic aciduria, a disorder characterized by the excessive excretion of orotic acid due to enzyme deficiency, resulting in megaloblastic anemia and developmental delays.
Uridine triacetate granules are suitable for both adults and children, offering emergency treatment for side effects within 4 days of florouracil or capecitabine administration. By shielding against their harmful effects, it prevents potential heart or brain-related side effects.
risk factors
Uridine is contraindicated in patients with:
- Known allergy or hypersensitivity to uridine.
- Pregnant and breastfeeding women.
- Non-emergent treatment of side effects linked with fluorouracil or capecitabine, as it may reduce their efficacy.
- Administration beyond 4 days or 96 hours following fluorouracil or capecitabine use.
side effects
Gastrointestinal: Common side effects may include vomiting, nausea, and diarrhea.
dosage
Uridine triacetate is provided as granules in 10-gram packets for oral administration. In adults, the recommended dose is 1 packet every 6 hours for a total of 20 doses, with or without food. For children, the dose is 6.2 grams/m2 of body surface area every 6 hours for 20 doses, with or without food.
how to take
Here are the instructions for preparing and administering uridine granules:
- Mix one packet of uridine granules (10 grams) with 4 ounces (100 ml) of soft food like applesauce, pudding, or yogurt in a small container.
- Crush the contents of one full 10-gram packet into a fine powder and add it to 4 ounces (100 ml) of starch-based thickening product.
- Maintain a ratio of no more than 1 gram per 10 ml of reconstituted food when giving to pediatric patients receiving less than 10 grams.
- Administer the mixture within 30 minutes of mixing and ensure the patient swallows all the medicine with at least 4 ounces of water.
- In children, adjust the dose based on their weight.
- If vomiting occurs, administer another full dose as soon as possible, followed by the next dose at the regular scheduled time.
- Measure the dose accurately using a scale or a graduated teaspoon.
- Complete the full course of 20 doses as directed by the doctor.
- If necessary, the medication can be given through a nasogastric tube or gastrostomy tube, particularly in cases of severe mouth inflammation (mucositis) or when the patient is in a coma.
warning
- The dose should not exceed 10 grams.
- Avoid chewing the granules.
- Do not use granules left in the open packet for subsequent dosing.