general
- Generic Name : Palbociclib
- Trade Names/Brand Names of Palbociclib : Ibrance
prescription
Palbociclib, a kinase inhibitor, is prescribed in combination with letrozole (an aromatase inhibitor) for the treatment of a specific type of hormone receptor-positive breast cancer—namely, estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer—in postmenopausal women. This treatment is applicable for cases that have reached an advanced stage or have metastasized to other parts of the body. Additionally, Palbociclib is used in combination with fulvestrant for women in whom the cancer continues to progress despite prior hormonal treatments. The mechanism of action involves blocking the activity of a specific protein that plays a crucial role in the multiplication of cancer cells.
risk factors
Palbociclib should be avoided in patients with known allergies to the drug, as well as in conjunction with specific medications, grapefruit juice, and St. John’s Wort. Additionally, its use is not recommended during pregnancy and breastfeeding. Individuals with liver or kidney disease should consult with their doctor before initiating the medication.
side effects
- General: Fatigue
- Gastrointestinal: Nausea, vomiting, diarrhea, decreased appetite, stomatitis (inflammation of the mucus membrane of the mouth).
- Respiratory: Shortness of breath, sudden chest pain due to pulmonary embolism, bleeding from the nose (epistaxis).
- Blood: Reduced counts of blood cells, including red blood cells, white blood cells, and platelets.
- Nervous system: Peripheral neuropathy (damage to the peripheral nerves).
- Hair: Unusual thinning of hair or hair loss.
dosage
The recommended dose of palbociclib is 125mg to be taken once daily for 21 days, followed by a 7-day break from treatment to complete a 28-day cycle.
how to take
Palbociclib is available in capsule form for oral administration, to be taken by mouth with food. It is prescribed in combination with letrozole (2.5mg), with the recommended dose being once daily. The capsule should be swallowed whole and should not be crushed, chewed, or opened before swallowing.
warning
- Palbociclib may lead to neutropenia, characterized by a reduced count of a specific type of white blood cell known as neutrophils. Regular monitoring of blood cell count is advisable during the course of the drug.
- If any signs or symptoms of pulmonary embolism (blood clot in the lung) occur after taking palbociclib with letrozole, immediate consultation with a doctor is recommended.
- Palbociclib should be avoided during pregnancy due to the potential harm it may pose to the fetus. Females of reproductive age taking the drug should use effective contraception.