general
- Generic Name : Abacavir Sulfate, Lamivudine and Zidovudine
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Pronunciation : a-BAK-a-vir/la-MIV-ue-deen/zye-DOE-vue-deen
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ICD Code : Y41.5
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Therapeutic Classification : Antiretroviral Agents
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International Name : Trizivir
prescription
Abacavir Sulfate, Lamivudine, and Zidovudine constitute a fixed-dose combination prescribed for the treatment of AIDS/HIV infection, especially for pregnant women to diminish the risk of mother-to-child transmission during pregnancy. This combination significantly decreases the likelihood of HIV resistance.
risk factors
- Hypersensitivity
side effects
- Most Common : Nausea, vomiting, headache, uneasiness, fatigue, diarrhea, fever, chills, depressive disorders, musculoskeletal pain, rash, throat infections, anxiety.
- Body : Redistribution/accumulation of body fat.
- Heart : Heart disease.
- Gastrointestinal : Mouth ulcer, Loss of appetite, abdominal pain, indigestion, darkening of skin
- Endocrine and Metabolic : Breast enlargement in males, sugar.
- General : Inflammation of blood cells, weakness.
- Blood : Anemia, swelling of lymph nodes, decrease in platelets.
- Liver – Lactic acidosis and hepatic steatosis (fatty liver), elevated bilirubin, elevated transaminases, posttreatment exacerbation of hepatitis B, jaundice (yellowing of the skin or eyes).
- Musculoskeletal : Joint pain, muscle pain, muscle weakness, symptomatic myopathy(diseases of skeletal muscle), CPK elevation, breakdown of muscle fibers.
- Central Nervous System : Dizziness, tingling, nerve disease, seizures, sleeplessness, and other sleep disorders.
- Respiratory : Abnormal breath sounds/wheezing, difficulty in breathing.
- Skin : Hair loss, redness, Stevens-Johnson syndrome, darkening of skin, rash, hives.
dosage
- Oral Dosage
- 1 tablet twice daily
how to take
- 300 mg / 150 mg / 300 mg
- With or woithout food
warning
- Exercise caution in patients with a history of kidney problems, heart disease, high blood pressure, high cholesterol, diabetes, bone marrow depression, muscle disorders, smoking, alcoholism, hepatitis B infection, breathing problems, nerve disorders, obesity, poor immunity, abdominal pain, diarrhea, nausea, vomiting, cough, sore throat, fever, fatigue, rash, any allergies, those taking other medications, and during pregnancy and breastfeeding.
- This medication may cause dizziness, so it is advised not to drive a car or operate machinery while taking it. It should not be used in children.
- Importantly, it does not prevent the spread of infection to others; therefore, it is recommended to avoid sexual contact and the sharing of needles or injection supplies.
storage
15° to 30°C